Evaluating and optimizing computational protein design force fields using fixed composition-based negative design
نویسندگان
چکیده
منابع مشابه
Evaluating and optimizing computational protein design force fields using fixed composition-based negative design.
An accurate force field is essential to computational protein design and protein fold prediction studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state. Here, we evaluate and optimize a protein design force field by constraining the amino acid composition of the designed sequences to that of a well behaved model protein. Accordin...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0805858105